[Assessment of the levels of neuron-specific enolase and BDNF at the stages of rehabilitation in the acute and early recovery periods of ischemic stroke].

E S Koroleva, N G Brazovskaya,L A Levchuk,S D Kazakov, N Y Romadina,V M Alifirova

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova(2020)

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摘要
NSE in patients was significantly higher than in the comparison group (<0.001) with a trend to a maximum decrease on the 90th day of stroke (<0.001). BDNF turned out to be lower than in the comparison group (=0.006) and significantly increased by the 14th day of the stroke (<0.001; =0.637). A negative correlation was found between a decrease in NSE and an increase in BDNF (= -0.349; =0.05). A positive correlation was found between an increase in BDNF and a decrease in mRS scores (=0.499, =0.035). Outcomes in patients in group 1 (after stages I and II of rehabilitation) on the assessment scales were significantly better than in patients discharged after stage I for outpatient monitoring - group 2 (<0.05). In group 1, BDNF did not differ from BDNF (=0.17), and in group 2 it was significantly lower by the end of the early recovery period (=0.002).
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关键词
brain-derived neurotropic factor,early recovery period,ischemic stroke,neuron-specific enolase,rehabilitation
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