Mechanisms of Resistance toSchistosoma japonicumInfection inMicrotus fortis, the Natural Non-permissive Host

Human schistosomiasis, which is caused by schistosomes, is a zoonosis that is difficult to control because of the many reservoir hosts. However,Microtus fortisis the only mammal that is naturally resistant toSchistosoma japonicuminfection known in China, in whichS. japonicumgrowth and development were arrested on day 12, and the worms eliminated on day 20 post-infection. In this review, we present an overview of the established and purported mechanisms of resistance toS. japonicuminfection inM. fortisin comparison toRattus norvegicus, a semi-permissive host. Clarifying the mechanism of this efficient resistance can help us to better understand host-parasite interaction and to provide better methods to control schistosomiasis.