Photoactive Metal-Organic Framework@Porous Organic Polymer Nanocomposites with pH-Triggered Type I Photodynamic Therapy

Photodynamic therapy (PDT) is a promising treatment for cancer, but the hypoxic tumor microenvironment limits its therapeutic effect, especially in these oxygen-dependent PDT-II systems. Herein, a nanoporous MOF@POP composite, named UBP, is synthesized by template strategy to effectively integrate BODIPY-contained porous organic polymers (POP) and MOF within one system. Such UBP possesses well dispersibility and pH-triggered type I photodynamic performance, which shows a selected toxicity to cancer cells (HeLa cells) but less damage to normal cells (L929 cells).