25-Hydroxyvitamin D Levels Are Low But Not Associated With Disease Activity In Chronic Spontaneous Urticaria And Depression

AIM: To evaluate vitamin D levels in patients with chronic spontaneous urticaria (CSU), depression and both of them, thus to find out whether vitamin D may be a common causative factor of CSU and depression.METHODS: Thirty patients with CSU, 30 patients with depression, 30 patients with both CSU and depression and 30 healthy volunteers as control group were involved in the study. Serum 25-hydroxyvitamin D (25(OH) D) levels of these groups were measured and compared. Correlations between 25(OH)D levels and the activity of CSU and depression were analyzed.RESULTS: Healthy controls' 25(OH)D levels (17.2 +/- 8.8 ng/mL) were higher than patients with CSU (9.1 +/- 5.1 ng/mL), depression (8.9 +/- 6.1 ng/mL) and CSU with depression (7.7 +/- 4.7 ng/mL) (p < 0.001, p < 0.001 and p<0.001, respectively). There were no differences in 25(OH)D levels between CSU patients with and without depression, between depression patients and CSU patients with and without depression (p=0.43, p= 0.82 and p=0.92, respectively). There were no correlations between 25(OH)D levels and the activity of CSU or depression (p= 0.99 and p= 0.76, respectively).CONCLUSION: Lower 25(OH)D levels in CSU and/or depression may appear as a secondary phenomenon, which means being result of these diseases rather than the cause (Tab. 1, Fig. 2, Ref. 41). Text in PDF www.elis.sk