GTP-cyclohydrolase deficiency induced peripheral and deep microcirculation dysfunction with age

Serge Simonet,Willy Gosgnach, Lucie Billou,Laurence Lucats,Emilie Royere,Christine Crespo,Isabelle Lapret, Lea Ragonnet, Kevin Moreau,Christine Vayssettes-Courchay, Pascal Berson,Marie-Pierre Bourguignon

Microvascular Research（2021）

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摘要

The present study assessed the impact of impaired tetrahydrobiopterin (BH4) production on vasoreactivity from conduit and small arteries along the vascular tree as seen during aging. For this purpose, the mutant hyperphenylalaninemic mouse (hph-1) was used. This model is reported to be deficient in GTP cyclohydrolase I, a rate limiting enzyme in BH4 biosynthesis. BH4 is a key regulator of vascular homeostasis by regulating the nitric oxide synthase 3 (NOS3) activity.

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关键词

GTP-cyclohydrolase I,BH4,Conduit blood vessel,Resistance blood vessel,Microcirculation,NOS3,NO,Age

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