Hla-Drb1*04:05andhla-Dqb1*04:01: Alleles Potentially Associated With Vogt-Koyanagi-Harada In Northern Thai Patients

Purpose To determine the frequency and association of alleles at human leukocyte antigen (HLA)-DRB1andHLA-DQB1loci in VKH disease patients from Northern Thailand. Methods A case-control study was conducted with three subject groups: 23 VKH patients, 20 patients with other uveitis entities, and 40 healthy blood donors.HLA-DRB1andHLA-DQB1loci were analyzed and the frequency ofHLA-DRB1andHLA-DQB1alleles was calculated by direct counting. The measure of association was calculated by odds ratio (OR) and 95% confidence interval. Results In VKH patients, the most prevalent allele wasHLA-DRB1*04:05, found in 35% of patients and with the highest OR (42.13).HLA-DQB1*04:01was the next most prevalent, found in 23.91% of VKH patients.HLA-DQB1*05:02was also detected in 23.91% of patients; however, a higher prevalence was observed in non-VKH and healthy controls (30% and 35%, respectively). ConclusionHLA-DRB1*04:05 andHLA-DQB1*04:01could be potential genetic markers for VKH.