Immobilized Random Peptide Mixtures Exhibit Broad Antimicrobial Activity With High Selectivity

Hadar Cheriker,Tal Stern Bauer, Yuval Oren,Shlomo Nir,Zvi Hayouka

CHEMICAL COMMUNICATIONS（2020）

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摘要

In the current study, we evaluated the antimicrobial activity of randomly-sequenced peptide mixtures (RPMs) bearing hydrophobic and cationic residues thatwere immobilized on beads. We showed that these beads exhibit high and broad bactericidal activity against various pathogenic bacteria while possessing minimal hemolytic activity.

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