Evolution of Colistin Resistance in the Klebsiella pneumoniae Complex Follows Multiple Evolutionary Trajectories with Variable Effects on Fitness and Virulence Characteristics (vol 65, e01958-20, 2021)

Axel B Janssen,Dennis J Doorduijn,Grant Mills,Malbert R C Rogers,Marc J M Bonten,Suzan H M Rooijakkers,Rob J L Willems,Jose A Bengoechea,Willem van Schaik

biorxiv（2021）

引用 12|浏览32

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摘要

Our study suggests that nosocomial complex strains can rapidly develop colistin resistance through diverse evolutionary trajectories upon exposure to colistin. This effectively shortens the lifespan of this last-resort antibiotic for the treatment of infections with multidrug-resistant .

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关键词

Klebsiella, antibiotic resistance, colistin, evolution, virulence

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