Improving qBOLD based measures of oxygen extraction fraction using hyperoxia-BOLD derived measures of blood volume

However, in the same group hqBOLD measures of OEF were found to be outside the physiological range in white matter regions (> 100%). By deriving maps of simulated R’ from TRUST and hyperoxia-BOLD imaging data, the hqBOLD overestimation of OEF in white matter was hypothesised to originate from additional sources of magnetic susceptibility beyond deoxyhaemoglobin that are present in white matter.