Pleiotropic effect of ABCG2 in gout: involvement in serum urate levels and progression from hyperuricemia to gout

biorxiv(2020)

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摘要
1, Department of Biochemistry, University of Otago, Box 56, Dunedin, New Zealand; 2, Rheumatic Diseases Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK; 3, Department of Rheumatology, University Clinic "CarlGustav-Carus", Dresden, Germany; 4, Department of Rheumatology, VieCuri Medical Center, Venlo, The Netherlands; 5, Department of Internal Medicine and Radboud Institute of Molecular Life Science, Radboud University Medical Center, Nijmegen, The Netherlands; 6, Department of Medical Genetics, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; 7, Laboratory of Rheumatology, University of Lausanne, CHUV, Nestlé 05-5029, 1011 Lausanne, Switzerland; 8, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti, NZ; 9, Department of Medicine, University of Otago, Christchurch, PO Box 4345, Christchurch, New Zealand; 10, Department of Medicine, University of Auckland, Auckland, New Zealand.
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关键词
Gout,urate,hyperuricemia,ABCG2,association,polymorphism
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