Inositol synthesis gene is required for circadian rhythm of Drosophila melanogaster mating behavior

Accumulating evidence indicates that the molecular circadian clock underlies the mating behavior of However, information about which gene affects circadian mating behavior is poorly understood in animals. The present study found that feeding -inositol enhanced the close-proximity (CP) rhythm of mating behavior and lengthened the period of the CP rhythm. Then, to understand a role for inositol synthesis to fly mating behavior, we established the (-inositol 1-phosphate synthase) knock down fly strains with RNAi. Interestingly, the CP behavior of this three-different driver knock down strains was arrhythmic, but the locomotor rhythm was rhythmic. The data of three-different knock down strains suggests that gene expression of upper LN, l-LN, 5s-LN in brain is necessary for proper CP rhythm generation in . The data indicated that the gene is involved in the role for the circadian rhythm of mating behavior.