Molecular markers characterization determining cell fate specification in an adult neurogenesis model of Alzheimer’s disease

Idoia Blanco-Luquin,Juan Cabello,Amaya Urdánoz-Casado,Blanca Acha,Eva Ma Gómez-Orte,Miren Roldan,Diego R. Pérez-Rodríguez,Maite Mendioroz

biorxiv（2020）

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摘要

Our human NPCs model is framed within the multistep process of AHN in the SGZ of the DG. Remarkably, its transcriptional assessment might reflect alterations detected in AD human patients, deepening our understanding of the disorder and possibly of its pathogenesis.

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关键词

Adult hippocampal neurogenesis,NPCs,Alzheimer&#x2019,s disease,A&#x03B2, peptide,Gene expression

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