A new mutant mouse model lacking mitochondrial-associated CB 1 receptor

Antonio C. Pagano Zottola,Edgar Soria-Gomez,Itziar Bonilla-del-Río,Carolina Muguruza,Geoffrey Terral,Laurie M. Robin,José F. Oliveira da Cruz,Bastien Redon,Thierry Lesté-Lasserre,Tarson Tolentino-Cortes,Nagore Puente,Gabriel Barreda-Gómez,Francis Chaouloff,Luis F. Callado,Pedro Grandes,Giovanni Marsicano,Luigi Bellocchio

biorxiv（2020）

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摘要

Besides their classical location at plasma membranes, CB receptors are present at different locations within cells, including in association to mitochondrial membranes (mtCB). Here we report the generation and characterization of a mutant mouse line, which lack mtCB receptors.

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关键词

CB<sub>1</sub> receptors,mitochondria,cannabinoids,bioenergetics

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