Insight towards the effect of the multi basic cleavage site of SARS-CoV-2 spike protein on cellular proteases

Kamal Shokeen,Shambhavi Pandey,Manisha Shah,Sachin Kumar

biorxiv（2022）

引用 6|浏览2

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摘要

•The interaction of S protein of SARS-CoV-2 with different host proteases like furin, cathepsin B, and plasmin.•The mutational analysis of S protein of SARS-CoV-2 with host cell proteases.•The molecular docking followed by MD simulation of single amino acid substitution in the S protein polybasic cleavage site .

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关键词

Spike protein,Proteolytic activation,Furin,Cathepsin B,Plasmin,MD simulations

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