A cooperative network of molecular “hot spots” highlights the complexity of LH3 collagen glycosyltransferase activities

Antonella Chiapparino,Francesca De Giorgi,Luigi Scietti,Silvia Faravelli,Tony Roscioli,Federico Forneris

biorxiv（2019）

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摘要

Collectively, our data provide a comprehensive overview of the complex network of shapes, charges and interactions that enable LH3 glycosyltransferase activities, expanding the molecular framework for the manipulation of glycosyltransferase functions in biomedical applications.

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关键词

Collagen biosynthesis,extracellular matrix,post-translational modifications,collagen glycosylations,glycosyltransferase,lysyl hydroxylase

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