The role of iron uptake systems in the pathogenesis of colistin-resistant hypervirulent K.pneumoniae infections

Ozlem Dogan,Cansel Vatansever,Nazli Atac,Ozgur Albayrak,Sercin Karahuseyinoglu, Ozgun Ekin Sahin,Bilge Kaan Kilicoglu, Atalay Demiray,Onder Ergonul,Mehmet Gönen,Fusun Can

biorxiv（2019）

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摘要

Iron uptake systems enhance successful survival of against neutrophil phagocytic defense, and stimulate excessive NET formation. The drugs targeted to iron uptake systems would be a promising approach for treatment of hypervirulent infections.

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