High prevalence of subtle systolic and diastolic dysfunction in genotype-positive phenotype-negative relatives of dilated cardiomyopathy patients

•LV GLS and PALS are promising tools for detection of subtle systolic and diastolic dysfunction, also in GPFN relatives of DCM patients.•In GPFN relatives of DCM patients have been identified lower values of both LV GLS and PALS, in compared to healthy subjects.•GPFN relatives of DCM patients with subtle systolic and diastolic dysfunction could require a tight follow-up for early identification of disease onset.