Multiscale activity imaging in mammary gland reveals how oxytocin enables lactation

biorxiv(2020)

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摘要
The mammary epithelium is indispensable for the continued survival of more than 5000 mammalian species. For some, the volume of milk ejected in a single day exceeds their entire blood volume. Here, we unveil the spatiotemporal properties of physiological signals that orchestrate milk ejection. Using quantitative, multidimensional imaging of mammary cell ensembles, we reveal how stimulus evoked Ca oscillations couple to contractions in basal epithelial cells. Moreover, we show that Ca-dependent contractions generate the requisite force to physically deform the innermost layer of luminal cells, compelling them to discharge the fluid that they produced and housed. Through the collective action of thousands of these biological positive displacement pumps, each linked to a contractile ductal network, milk is delivered into the mouth of the dependent neonate, seconds after the command.
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关键词
Calcium signaling,genetically-encoded calcium indicators,oscillations,mammary gland,oxytocin.
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