ASIC1a regulates miR-350/SPRY2 by N 6 -methyladenosine to promote liver fibrosis

Yueqin Zhu
Yueqin Zhu
Xuesheng Pan
Xuesheng Pan
Na Du
Na Du
Kuayue Li
Kuayue Li
Yamin Hu
Yamin Hu
Lili Wang
Lili Wang
Yanyi Liu
Yanyi Liu
Longquan Zuo
Longquan Zuo
Chengmu Hu
Chengmu Hu
Xian Wu
Xian Wu

FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020.

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Keywords:
ASIC1aHSCMETTL3SPRY2miR-350

Abstract:

As a reversible scar repair reaction, liver fibrosis can be blocked or even reversed by proper intervention during its formation. Our work suggests that acid-sensitive ion channel 1a (ASIC1a) participates in liver fibrosis and presents a novel mechanism involving m A modification and miR-350/SPRY2. We demonstrated that the expression of A...More

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