Successful DAA therapy for chronic hepatitis C reduces HLA-DR on monocytes and circulating immune mediators: A long-term follow-up study

Natalia Fonseca Rosário,Geórgia do Nascimento Saraiva,Thalia Medeiros,Mariana Gandini,Gilmar de Souza Lacerda,Paulo Emílio Corrêa Leite,Thaís Guaraná de Andrade,Elzinandes Leal de Azeredo,Analúcia Rampazzo Xavier,Andrea Alice Silva

Immunology Letters（2020）

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摘要

•Long-term sustained reduction in immune mediators occurs after HCV eradication.•Greater immune modulation occurs in experimented patients after DAA therapy.•Monocyte activation status is reduced in one year after the end of DAA therapy.•Liver stiffness improvement occurs after successful DAA therapy.•Successful DAA treatment enables a scenario of inflammatory status restoration.

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1y,DCV,RBV,SD,SMV,SOF,SVR

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