Trading Genome Vulnerability for Stable Genetic Inheritance: Active Retrotransposons Help Maintain Pericentromeric Heterochromatin Required for Faithful Cell Division

Yajing Hao
Yajing Hao
Dongpeng Wang
Dongpeng Wang
Shuheng Wu
Shuheng Wu
Xiao Li
Xiao Li
Do-Hwan Lim
Do-Hwan Lim
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Abstract:

Retrotransposons are extensively populated in vertebrate genomes, which, when active, are thought to cause genome instability with potential benefit to genome evolution. Retrotransposon-derived RNAs are also known to give rise to small endo-siRNAs to help maintain heterochromatin at their sites of transcription; however, as not all hetero...More

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