Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect
Acta pharmacologica Sinica, 2020.
Akt/mTOR/PKM2/HIF-1α signaling.M2-type pyruvate kinaseWarburg effectacute liver failureglycolysisMore(2+)
Acute liver failure (ALF) is a fatal clinical syndrome with no special drug. Recent evidence shows that modulation of macrophage to inhibit inflammation may be a promising strategy for ALF treatment. In this study we investigated the potential therapeutic effects of melittin, a major peptide component of bee venom both in mice model of AL...More
Full Text (Upload PDF)
PPT (Upload PPT)