Melittin ameliorates inflammation in mouse acute liver failure via inhibition of PKM2-mediated Warburg effect

Si-Ya Pei
Si-Ya Pei
Dan Zhou
Dan Zhou
Peng-Cheng Zhou
Peng-Cheng Zhou
Teng Li
Teng Li
Ze-Bing Huang
Ze-Bing Huang

Acta pharmacologica Sinica, 2020.

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Keywords:
Akt/mTOR/PKM2/HIF-1α signaling.M2-type pyruvate kinaseWarburg effectacute liver failureglycolysisMore(2+)

Abstract:

Acute liver failure (ALF) is a fatal clinical syndrome with no special drug. Recent evidence shows that modulation of macrophage to inhibit inflammation may be a promising strategy for ALF treatment. In this study we investigated the potential therapeutic effects of melittin, a major peptide component of bee venom both in mice model of AL...More

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