Relief Of Lower Urinary Tract Symptoms After Mri-Guided Transurethral Ultrasound Ablation For Localized Prostate Cancer: Subgroup Analyses In Patients With Concurrent Cancer And Benign Prostatic Hyperplasia

Background: MRI-guided transurethral ultrasound ablation (TULSA) offers minimally invasive thermal ablation of benign and malignant prostate tissue, using directional high-intensity ultrasound and real-time, magnetic resonance thermometry feedback control. Feasibility of TULSA for alleviating lower urinary tract symptoms (LUTSs) associated with benign prostatic hyperplasia (BPH) is retrospectively assessed in a subgroup of men from a localized prostate cancer study who also had LUTSs.Patients and Methods: TULSA was used to ablate 90% of the prostate gland in 30 men with localized prostate cancer, without plans to spare ejaculatory ducts. Mean +/- standard deviation treatment time was 37 +/- 10 minutes. Retrospective analysis was conducted on a subpopulation of nine patients who also suffered from LUTSs (International Prostate Symptom Score [IPSS] >= 12 at baseline) as well as a smaller subgroup of five patients with IPSS >12 and peak urinary flow (Q(max)) <15 mL/second. Urinary symptom relief, continence, and erectile function were assessed using IPSS, International Index of Erectile Function (IIEF), and uroflowmetry.Results: At 12 months post-TULSA, IPSS improved significantly by 58% to 6.3 +/- 5.0 (p = 0.003), with at least a moderate (>= 6 points) reduction in eight of nine patients. IPSS quality of life improved in eight of nine patients. Erectile function (IIEF-EF) remained stable from 14.6 +/- 9.3 at baseline to 15.7 +/- 9.0 at 12 months. The proportion of patients with erections sufficient for penetration (IIEF Q2 >= 2) was unchanged. Full urinary continence (pad free and leak free) was achieved at 12 months in all patients. In five men who suffered from more severe symptoms, Q(max) increased from 11.6 +/- 2.6 mL/second to 22.5 +/- 14.2 mL/second at 12 months (p = 0.126). Perfused prostate volume, measured on MRI, decreased 70% to 13.6 +/- 4.6 mL (p = 0.003) at 12 months. All adverse events were mild to moderate (Common Terminology Criteria for Adverse Events [CTCAE] Grade 1-2) with no serious events reported.Conclusions: This retrospective analysis demonstrates promising safety and feasibility of TULSA to relieve LUTSs, with improvement in IPSS comparable with modern, minimally invasive surgical therapies. Larger controlled studies with BPH-specific ablation plans in men seeking treatment for LUTSs are warranted.