Characterisation of the secreted apyrase family of Heligmosomoides polygyrus

Rita Berkachy,Danielle J. Smyth,Corinna Schnoeller,Yvonne Harcus,Rick M. Maizels,Murray E. Selkirk,Kleoniki Gounaris

International Journal for Parasitology（2021）

引用 4|浏览20

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摘要

•Heligmosomoides polygyrus secretes apyrases homologous to soluble calcium-activated nucleotidases.•Apyrases hydrolyse nucleoside triphosphates and diphosphates.•Expression is restricted to adults and L4s.•Vaccination with recombinant apyrases generates partial protection against infection.

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关键词

Apyrase,Nematode,Helminth,Heligmosomoides polygyrus,Vaccination

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