Rhodium-Catalyzed Transarylation of Benzamides: C-C Bond vs C-N Bond Activation
ACS CATALYSIS(2020)
摘要
A rhodium-catalyzed transarylation of benzamides via selective C-C bond activation with arylboronic acids was described, which was distinct from the conventional metal-catalyzed C-N bond activation. This transformation exhibited good functional group compatibility with yields up to 88%, offering a practical approach for the construction and functionalization of benzamides. Preliminary experimental and computational studies revealed the selectivity of metal insertion into the C-C bond or the C-N bond was greatly affected by substituents on the amide's N atom.
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关键词
amide,C-C activation,C-H activation,arylation,rhodium catalysis,DFT
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