Assembly Of Polysubstituted Chiral Cyclopropylaminesviahighly Enantioselective Cu-Catalyzed Three-Component Cyclopropene Alkenylamination

Enabled by a commercial bisphosphine ligand, the Cu-catalyzed three-component cyclopropene alkenylamination with alkenyl organoboron reagent and hyroxyamine esters proceeds with exceptionally high enantioselectivity to deliver poly-substitutedcis-1,2-alkenylcyclopropylamines that contain up to all three stereogenic centers on the cyclopropane.