Overexpression of Prolidase Induces Autophagic Death in MCF-7 Breast Cancer Cells.

Ilona Zareba,Thi Yen Ly Huynh,Adam Kazberuk,Joanna Teul,Agnieszka Klupczynska,Jan Matysiak,Arkadiusz Surazynski,Jerzy Palka

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2020）

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摘要

BACKGROUND/AIMS:Proline availability for proline dehydrogenase/proline oxidase (PRODH/POX) may represent switching mechanism between PRODH/POX-dependent apoptosis and autophagy. The aim of the study was to evaluate the impact of overexpression of prolidase (proline releasing enzyme) on apoptosis/autophagy in breast cancer MCF-7 cells. METHODS:The model of MCF-7 cells with prolidase overexpression (MCF-7 PLRESULTS:Prolidase overexpression in MCF-7 PLPLPLPLPLCONCLUSION:The data suggest that overexpression of prolidase in MCF-7 cells contributes to increase in intracellular proline concentration and PRODH/POX-dependent autophagic cell death.

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关键词

Prolidase, Proline, Autophagy, Collagen biosynthesis, Breast cancer cells MCF-7

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