Beyond structural models for the mode of action: How natural antimicrobial peptides affect lipid transport
Journal of Colloid and Interface Science(2021)
摘要
Hypothesis: Most textbook models for antimicrobial peptides (AMP) mode of action are focused on structural effects and pore formation in lipid membranes, while these deformations have been shown to require high concentrations of peptide bound to the membrane. Even insertion of low amounts of peptides in the membrane is hypothesized to affect the transmembrane transport of lipids, which may play a key role in the peptide effect on membranes.
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关键词
Antimicrobial peptides,Lipid membranes,Lipid transport,Neutron scattering,X-ray scattering
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