Impact Of Scanner Harmonization On Pet-Based Treatment Response Assessment In Metastatic Melanoma

Patients with metastatic melanoma often receive F-18-FDG PET/CT scans on different scanners throughout their monitoring period. In this study, we quantified the impact of scanner harmonization on longitudinal changes in PET standardized uptake values using various harmonization and normalization methods, including an anthropomorphic PET phantom. Twenty metastatic melanoma patients received at least two FDG PET/CT scans, each on two different scanners with an average of 4 months (range: 2-8) between. Scans from a General Electric (GE) Discovery 710 PET CT-1 were harmonized to the GE Discovery VCT using image reconstruction settings matching recovery coefficients in an anthropomorphic phantom with bone equivalent inserts and wall-less synthetic lesions. In patient images, SUVmax was measured for each melanoma lesion and time-point. Lesions were classified as progressing, stable, or responding based on pre-defined threshold of +/- 30% change in SUVmax. For comparison, harmonization was also performed using simpler methods, including harmonization using a NEMA phantom, post-reconstruction filtering, reference region normalization of SUVmax, and use of SUVpeak instead of SUVmax. In the 20 patients, 90 lesions across two time-points were available for treatment response assessment. Treatment response classification changed in 47% (42/90) of cases after harmonization with anthropomorphic phantom. Before harmonization, 37% (33/90) of the lesions were classified as stable (changing less than 30% between two time-points), while the fraction of stable lesions increased to 58% (52/90) after harmonization. Harmonization with the NEMA phantom agreed with harmonization with the anthropomorphic phantom in 91% (82/90) of cases. Post-reconstruction filtering agreed with anthropomorphic phantom-based harmonization in 83% (75/90) cases. The utilization of reference regions for normalization or SUVpeak was unable to correct for changes as identified by the anthropomorphic phantom-based harmonization. Overall, PET scanner harmonization has a major impact on individual lesion treatment response classification in metastatic melanoma patients. Harmonization using the NEMA phantom yielded similar results to harmonization using anthropomorphic phantom, while the only acceptable post-reconstruction technique was post-reconstruction filtering. Phantom-based harmonization is therefore strongly recommended when comparing lesion uptake across time-points when the images have been acquired on different PET scanners.