Mitochondria in Ovarian Aging and Reproductive Longevity

•Ovarian aging is one of the etiological factors in infertile women.•Mitochondrial dysfunction drives ovarian aging.•Rejuvenating mitochondria with nutrient therapy may improve fertility.•Optimizing mitochondria by lifestyle or environment prolongs reproductive longevity.•Mitochondrial replacement therapy for in vitro fertilization is being investigated.