ALK-rearranged lung adenocarcinoma transformation into high-grade large cell neuroendocrine carcinoma: Clinical and molecular description of two cases

Aline F. Fares,Benjamin H. Lok,Tong Zhang,Michael Cabanero,Sally C.M. Lau,Tracy Stockley,Devalben Patel,Penelope A. Bradbury,Adrian Sacher,Kazuhiro Yasufuku, Barbara A. Morash,Peter J.B. Sabatini, Lananhn N. Nguyen,Natasha B. Leighl,Ming-Sound Tsao,Frances A. Shepherd,Geoffrey Liu,Sebastiao N. Martins-Filho,Prodipto Pal

Lung Cancer（2020）

引用 12|浏览16

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摘要

•First two cases of ALK-rearranged LUAD that transformed to high-grade LCNEC after ALK-TKI treatment.•Development of on-target ALK G1202R mutation, showing unique dual mechanisms of resistance in both cases.•Different RB1 status in both cases, with worse outcome in the case with RB1 loss.

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关键词

ALK-translocation,Large-cell-neuroendocrine-carcinoma,Histologic-transformation

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