COMPARISON OF OUTCOMES BETWEEN PATIENTS WITH MYC REARRANGED DLBCL AND DOUBLE/ TRIPLE HIT HIGH‐GRADE B CELL LYMPHOMA: A PAN …

Dima El‐Sharkawi, Sarkhara Sharma,Lucy Cook, Brian Hanley, Rosalynd Johnston,Anita Arasaretnam, Ioanna Lazana,Paul Greaves, Amy Parkinson, Ying Peng,Shireen Kassam, Victoria Peacock, Richard Kaczmarski,Mark Bower,Betty Cheung,Corinne De Lord,Matthew Cross,Katherine Vroobel,Andrew Wotherspoon, Frances Aldridge,Jahanzaib Khwaja,Bhupinder Sharma,Kate Cwynarski,Ruth Pettengell,Ian Chau,David Cunningham,Kikkeri Naresh,Sunil Iyengar

Hematological Oncology（2019）

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摘要

Methods: MiRNA targets within gene transcripts were predicted in silico using the TargetScan software.Results: MiRNAs miR-17, miR-18, miR-19, miR-20, miR-21, miR-29, miR-92, miR-106, miR-144, miR-146, miR-155, miR-221/222, miR-363, miR-500 and miR-574, hyperexpression of which is essential for DLBCL cells, can target transcripts of genes encoding many DNA repair enzymes as well as other DNA damage response proteins that are key elements of all DNA repair systems–base excision repair

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