A closer look at the natural history and recurrence patterns of high-grade truncal/extremity leiomyosarcomas: A multi-institutional analysis from the US Sarcoma Collaborative.

•High risk soft tissue sarcomas are defined as high grade and >5 cm in size.•Standard of care is multi-modality therapy with surgery and radiation.•Leiomyosarcomas may have more aggressive biology than other histological subtypes.•Radiation may not have a benefit for Leiomyosarcomas.•Prospective studies are needed to investigate this finding.