Efficacy and safety of anti-inflammatory agents in treatment of psychotic disorders – A comprehensive systematic review and meta-analysis

•Anti-inflammatory add-on treatment shows effects for psychotic disorders.•The effect was larger for schizophrenia than other psychotic disorders.•Primarily anti-inflammatory drugs were not superior to the other included drugs.•Meta-regression showed decreasing effects with increasing sample sizes.•Future studies should include markers of inflammation to assess drug effects.