The endoplasmic reticulum-resident serpentine receptor SR10 has important functions for asexual and sexual blood stage development of Plasmodium falciparum

Emilie Joëlle Njila Tchoufack, Lena Hahnfeld, Georg Pitschelatow,Sandra Bennink,Gabriele Pradel

Molecular and Biochemical Parasitology（2020）

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摘要

•The genome of Plasmodium falciparum encodes the serpentine receptor SR10.•SR10 is expressed in the asexual and sexual blood stages of P. falciparum.•SR10 associates with the endoplasmic reticulum of the P. falciparum blood stages.•Loss of SR10 impairs intraerythrocytic replication and gametocyte development.

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关键词

Plasmodium falciparum,Serpentine receptor,Seven-Helix protein,Endoplasmic reticulum,Blood stage replication,Gametocyte,Malaria

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