Blood–cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA

Ha Ngo-Thanh,Tsutomu Sasaki,Kazutomo Suzue,Hideaki Yokoo, Koji Isoda,Wataru Kamitani,Chikako Shimokawa,Hajime Hisaeda,Takashi Imai

International Journal for Parasitology（2020）

引用 12|浏览17

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摘要

•A new method to evaluate the integrity of the blood–cerebrospinal fluid barrier (BCSFB) was developed.•BCSFB permeability was increased specifically in cerebral malaria (CM), but not in non-CM.•CD8+ T cells are involved in the BCSFB breakdown during CM.•Hemozoin was found in the choroid plexus in CM.

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关键词

Experimental cerebral malaria,Blood–cerebrospinal fluid barrier,Choroid plexus,Hemozoin pigment,CD8+ T cell

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