Structural and Functional Characterization of C0021158, a High-Affinity Monoclonal Antibody That Inhibits Arginase 2 Function Via a Novel Non-Competitive Mechanism of Action Mark Austin , Daniel Burschowsky , Denice T. Y. Chan , Lesley Jenkinson , Stuart Haynes , Agata Diamandakis , Chitra Seewooruthun , Alexandra Addyman , Sebastian Fiedler , Stephanie Ryman , Jessica Whitehouse , Louise H. Slater , Andreas V. Hadjinicolaou , Uzi Gileadi , Ellen Gowans , Yoko Shibata , Michelle Barnard , Teresa Kaserer , Pooja Sharma , Nadia M. Luheshi , Robert W. Wilkinson , Tristan J. Vaughan , Sarah V. Holt , Vincenzo Cerundolo , Mark D. Carr , Maria A. T. Groves MABS（2020）
关键词
ARG2, Arginase 2, antibody co-crystal structure, phage display selections, cancer therapeutics, ARG2 epitope, human monoclonal antibody, ARG2 neutralization
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