PPARγ enhanced Adiponectin polymerization and trafficking by promoting RUVBL2 expression during adipogenic differentiation

Daiyun Zhu,Le Xu, Xuan Wei,Benzeng Xia,Yuqing Gong,Qinjin Li,Xiaodong Chen

Gene（2021）

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摘要

•The expression of PPARγ, RUVBL2 and Adiponectin during adipogenic differentiation.•PPARγ promoted adiponectin trafficking and adipocyte differentiation by RUVBL2.•RUVBL2 stimulated the expression, polymerization and secretion of adiponectin.•PPARγ up-regulated RUVBL2 expression by binding directly to RUVBL2 promoter DNA.

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关键词

AdipoR,Akt,AS160,ER,GLUT4,GW,HMW,LMW,ORO,PPAR,PPRE,RUVBL2,RXR,TNF-α,AdipoR1

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