Prevalence of antiretroviral drug resistance mutations among pre-treatment and ART-failured HIV patients in Uzbekistan.

The molecular-epidemiological profile of HIV infection in Uzbekistan has changed towards a predominance of CRF02_AG viruses. The first national scale study of the PDR prevalence it was found to be relatively low (2.96%). The DR mutations in failured patients correspond to the main treatment regimens (NRTI/NNRTI) adopted in the country. The observations provide new evidence for differences in ART efficacy and resistance profiles for different subtypes.