A new lipophilic amino alcohol, chemically similar to compound FTY720, attenuates the pathogenesis of experimental autoimmune encephalomyelitis by PI3K/Akt pathway inhibition

Luan Cristian da Silva,Isabel Vieira de Assis Lima,Maria Carolina Machado da Silva,Taís Arthur Corrêa,Viviane Passos de Souza,Mauro Vieira de Almeida,Antônio Carlos Pinheiro de Oliveira,Ana Paula Ferreira

International Immunopharmacology（2020）

引用 7|浏览16

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摘要

•A new lipophilic amino alcohol compound (4b) inhibited the worsening of EAE.•Compound 4b inhibited the spinal cord demyelination in EAE mice.•Compound 4b regulated the neuroinflammatory parameters in EAE mice.•PI3K/Akt pathway was regulated in the CNS of EAE mice after treatment with 4b.

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关键词

Multiple sclerosis,Experimental autoimmune encephalomyelitis,Fingolimod analogue,PI3K,Akt

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