Arekif6andapoepolymorphisms Associated With Power And Endurance Athletes?

Genetic polymorphisms within physiologically relevantKIF6andAPOEgenes were examined in the context of athletic performance. KIF6 and ApoE are involved in cardiovascular health, modulation of lipid level and neurotransmission amongst others. The aim of this study was to examine whether three polymorphisms,KIF6rs20455T > C,APOErs429358T > C andAPOErs7412 C > T, were associated with athletic status of an athlete defined as performance type (endurance or power). Genotyping was performed using real-time PCR on buccal genomic DNA from 204 Polish athletes including 104 endurance and 100 power athletes, and 161 sedentary individuals.APOErs429358 genotype frequencies differed significantly between power athletes and sedentary individuals (p = 0.046).KIF6rs20455 andAPOErs7412 were found to be epistatically associated with the power athletic status (p = 0.032).KIF6rs20455,APOErs429358 andAPOErs7412 were associated with athletic status of Polish athletes. In the future, these polymorphisms could contribute to predictive models aimed at assessment of an individual's athletic status.