Neutrophil surged for mortality of COVID 19: a correlational study

Research Square(2020)

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摘要
Background: Multiorgan damage by SARS-CoV-2 results in alterations of many clinical measures associated with mortality of COVID-19. This research discussed the pioneering pathogenicity factors that lead to the extensive damage elusive.Objectives: A cohort of COVID-19 patients.Methods: We conducted a correlational analysis of hospital outcomes with an independent cohort of COVID-19 patients and we also presented a death case to illustrate for time course of immune cell density.Results: The results showed that dysregulated immune cell densities were correlated with hospitalization duration before death, not before discharge. High neutrophil densities allowed sorting out one third of total death cases while a density of less than 70% of the white blood cells allowed sorting out 70% of surviving cases.Conclusion: Collectively surged neutrophil was a top trigger for mortality in patients with COVID-19.
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mortality
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