Whole transcriptome in silico screening implicates cardiovascular and infectious disease in the mechanism of action underlying atypical antipsychotic side effects.

Yasaman Malekizadeh,Gareth Williams,Mark Kelson,David Whitfield,Jonathan Mill,David A Collier,Clive Ballard,Aaron R Jeffries,Byron Creese

Alzheimer's & dementia (New York, N. Y.)（2020）

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摘要

These findings for the first time mechanistically link antipsychotics to specific cardiovascular and infectious diseases which are known side effects of their use in dementia, providing new information to explain related adverse events.

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关键词

RNA‐seq,amisulpride,antipsychotic,brain derived neurotrophic factor,cardiovascular,immune,platelet derived growth factor,risperidone,selenium,side effects,tumor necrosis factor

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