Exploring imaging features of molecular subtypes of large cell neuroendocrine carcinoma (LCNEC)

B C M Hermans,S Sanduleanu,J L Derks,H Woodruff,L M Hillen, R Casale,F Mohamed Hoesein,E de Jong, D M H J Ten Berge,E J M Speel,P Lambin, H A Gietema,A-M C Dingemans

Lung Cancer（2020）

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摘要

•LCNEC has radiological characteristics of both SCLC and NSCLC.•LCNEC can be classified in molecular SCLC-like and NSCLC-like subtypes.•Molecular LCNEC subtypes could not be identified based on radiological imaging.•Most LCNEC are molecular SCLC-like, but have a radiological NSCLC-like appearance.•These results highlight LCNEC as a unique tumor entity.

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关键词

LCNEC,large cell neuroendocrine carcinoma,radiomics,semantic features,radiological features

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