Salvia ceratophylla L. from South of Jordan: new insights on chemical composition and biological activities
NATURAL PRODUCTS AND BIOPROSPECTING(2020)
摘要
In Jordan, Salvia ceratophylla L. is traditionally used in the treatment of cancer, microbial infections, and urinary disorders. This study aimed: (1) to chemically characterize S. ceratophylla essential oil (EO) from South Jordan, by gas chromatography (GC) and gas chromatography-mass spectrometry (GC–MS); and (2) to evaluate in vitro the cytotoxic, anti-inflammatory, and antiprotozoal activities of the EO, it’s predominant components, and the hexane (A), ethyl acetate (B), methanol (C) and crude-methanol extracts (D). The analysis revealed that the EO has 71 compounds, with linalool (54.8%) as main constituent. Only the hexane extract (A) showed some cytotoxic activity against SK-MEL, KB, BT-549, SK-OV-3, LLC-PK1 and VERO cells lines with IC 50 between 60 and > 100 µg/mL. The EO inhibited NO production (IC 50 90 µg/mL) and NF-κB activity (IC 50 38 µg/mL). The extracts A, B, and D inhibited NO production and NF- κB activity with IC 50 between 32 and 150 µg/mL. Linalool considerably inhibited NO production (IC 50 18 µg/mL). The extracts tested did not exhibit antileishmanial activity. Regarding antitrypanosomal activity, the EO exhibited significant results with IC 50 2.65 µg/mL. In conclusion, Jordan S. ceratophylla EO represents a rich source of linalool and bears a promising therapeutic potential for further antitrypanosomal drug development.
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关键词
Lamiaceae,Essential oil,Chemical composition,Cytotoxicity,Anti-inflammatory activity,Neglected diseases
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