Modeling and Simulation Analysis of Aprepitant Pharmacokinetics in Pediatric Patients With Postoperative or Chemotherapy-Induced Nausea and Vomiting.

Anne Chain, Rebecca Wrishko, Grygoriy Vasilinin, Samer Mouksassi

The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG（2020）

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摘要

The developed population PK model adequately described aprepitant PK across a broad pediatric population, justifying fixed (adult) dosing for adolescents and weight-based dosing of oral aprepitant for children.

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关键词

CINV,PK,aprepitant,chemotherapy-induced nausea and vomiting,modeling and simulations,pediatric,pharmacokinetics

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