Adherence to the MIND diet in relation to glioma: a case-control study

Objectives: Although some components of MIND diet have been shown to have favorable association with glioma, no information exist about the potential link between adherence to the whole MIND diet and risk of glioma. This study was conducted to examine the association between adherence to MIND diet and risk of glioma in a group of Iranian adults. Methods: In this hospital-based case-control study, 128 newly diagnosed glioma cases and 256 age- and sex-matched controls were included. Dietary intakes of study participants were assessed using a validated 126-item semi-quantitative FFQ. The MIND diet score was computed based on participants' dietary intakes obtained from FFQ. Conditional logistic regression models were used to examine the association between the MIND diet score and glioma. Results: After controlling for age, sex and energy intake, individuals with the greatest adherence to the MIND diet were less likely to have glioma compared with those with the lowest adherence; such that those in the top tertile were 47% less likely to have glioma than those in the bottom tertile (OR: 0.53; 95% CI: 0.30-0.94). Further adjustment for other potential confounders strengthened the association (OR for the highest tertile vs. the lowest: OR: 0.37; 95% CI: 0.18-0.79). Additional controlling for BMI did not influence the association significantly (OR: 0.39; 95% CI: 0.18-0.84). Discussion: In conclusion, we found that adherence to the MIND diet might be inversely associated with odds of glioma in this case-control study. Further studies are required to confirm these findings.