Autophagy was involved in tumor necrosis factor-α-inhibited osteogenic differentiation of murine calvarial osteoblasts through Wnt/β-catenin pathway.

Lili Chen,Jiaqi Bao,Yuting Yang,Zhongxiu Wang,Mengjiao Xia,Jingyi Tan,Lili Zhou,Yanmin Wu,Weilian Sun

Tissue and Cell（2020）

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摘要

•TNF-α inhibited the autophagy of murine calvarial osteoblasts.•Autophagy was a positive regulator of osteogenic differentiation.•Inhibition of autophagy could suppress Wnt/β-catenin signaling pathway. during impaired osteogenic differentiation.

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关键词

TNF-α,Osteoblasts,Autophagy,Wnt/β-catenin pathway

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