IDH1 MUTANT GLIOBLASTOMA: EVIDENCE FOR SEQUENCED MOLECULAR EVOLUTION FROM A DEVELOPMENTALLY RESTRICTED CELL OF ORIGIN

Neuro-oncology（2010）

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摘要

Most glioblastoma multiformes (GBMs) arise de novo with no prior clinical history of a precursor lesion and are referred to as primary GBMs, while a minority of GBM cases, known as secondary GBMs, develop from lower-grade gliomas. The recent discovery that most low-grade gliomas and secondary GBMs h

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