Analysis Of Phosphotyrosine Signaling In Glioblastoma Implicates Nuclear Egfrviii-Stat5b Complex In The Induction Of Bcl-Xl Expression

Khatri Latha,Vaibhav Chumbalkar,Ming Li,Anupama Gururaj,Yeohyeon Hwang,Rebecca Maywald,Sumana Dakeng,Lixia Dao,Keith Baggerly,Raymond Sawaya,Kenneth Aldape,Webster Cavenee,Frank Furnari,Oliver Bogler

Neuro-oncology（2010）

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摘要

Aberrant EGFR signaling is a major contributing force to glioma progression and treatment resistance. The most prevalent mutation, ΔEGFR/EGFRvIII, is an inframe deletion of the extracellular domain, occurring in the about 40% of glioblastomas and promoting growth and survival of tumor cells. The sig

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